DAPTOMYCIN POPULATION PHARMACOKINETICS IN PATIENTS AFFECTED BY SEVERE GRAM-POSITIVE INFECTIONS: AN UPDATE

Daptomycin pharmacokinetics may not depend on renal function only and it significantly differs between healthy volunteers and severely ill patients.Herein, we propose a population pharmacokinetics model based on 424 plasma daptomycin concentrations collected from 156 patients affected by severe Gram-positive infections during a routine therapeutic

Abstract Background Searching a database of protein structures for matches to a query structure, or occurrences of a structural motif, is an important task in structural biology and Fuser Maintenance Kit bioinformatics.While there are many existing methods for structural similarity searching, faster and more accurate approaches are still required,